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Artificial skin A ray of hope for burn patients

Artificial skin A ray of hope for burn patients
Artificial skin A ray of hope for burn patients

You may have seen patients in hospitals suffering from burns due to fire. Their burnt faces become ugly, so they hide their face or body. Such patients become psychologically frustrated or frustrated. Although plastic surgery has progressed a lot in the present era and the treatment of burnt patients is easy, it costs a lot. Therefore, it has become a dream for patients in this homeland.

The patients who do not get proper treatment, they are forced to live with their scarred and ugly skin, or else they wash their hands of life. However, there is a ray of hope for the patients burnt by the fire that the local Pakistanis Doctors and scientists have announced that they will mass-produce artificial skin in a personal laboratory.

There has been progress in this matter because an agreement has been reached between the University of Health Sciences and two associations of Pakistan in this regard. The first such artificial skin from abroad is calculated at $900 (Rs. 127,440) per inch. Used to be imported from, but now the same type of human skin can be produced in Pakistan for 1000 rupees.

With this artificial skin, patients with extensive burns will be able to heal.

They will also include those patients whose body has been burnt up to 70%. The process of implanting artificial skin in place of human skin started in Pakistan for the first time locally in 2015, however, it was done experimentally, and now this skin is being developed on a large scale, benefiting a large number of patients. It will be possible.

Prof. Javed Ikram, vice chancellor of the University of Health Science, while explaining the details, said that there are various causes of death by burning, including different types of infections, water leakage from the cells, and minerals from the victim's body. Does not include rapid loss.

He added that the mortality rate of patients is higher because they are burned up to 90% instead of 70%. When artificial skin will be widely developed in our own laboratory, the suffering of affected people will be reduced to 20%. and the chances of survival of patients will increase.

In fact, artificial skin imported from abroad is very expensive, especially for middle-class patients, so they avoid treatment and end up dying as a result.

Recalling the oil tanker accident in Ahmedpur Sharqi, he said that many deaths occurred in this accident only because artificial skin was not available in large numbers in our hospitals. Some of it will be very cheap compared to imported skin from Europe and America, but its quality will be the same as the same skin.

The fact is that the skin that we will produce in Pakistan will prove to be better than the imported skin in many ways. praising it as suitable and useful for burn patients. We used this skin on many patients as an experiment and they were blessed with healing.

Explaining the methods of skin replacement, Professor Javed Akram said that there are two methods:

 one method is called technical and the other is regulatory. Technically, we have made 17 inventions, including artificial skin, human eye pupils, and kidneys. Cells and "INTERFERON INJECTION" (INTERFERON INJECTION), which is administered to patients with liver inflammation (hepatitis), are included.

The job of scientists is to invent things in the laboratory, but the real thing is when these things are used on patients and they get healing.

Dr. Javed Ikram also mentioned the obstacles that he is facing in the production of artificial skin. The biggest problem is the rules and regulations. Then there are problems in the matter of registration, that is, we have prepared it soon, but it is not understood which entity will register it? Which pharmaceutical company will manufacture it on a commercial scale and market it for sale.

Initially, we faced a lot of difficulties in this regard.

The drug mafia, which is importing synthetic skin and different types of drugs from foreign countries, lost its interest, so it started obstructing our work. Also, the medicinal chemicals we used to demand were either not available or artificially scarce, which hampered our work.

I am very grateful to the Supreme Court of Pakistan for taking suo moto action (judicial authority to take action against corruption if it sees any corruption, not waiting for someone else to file a claim) and forming a committee. That he should supervise the affairs. With this court decision we got success, we got rid of confusion, and started manufacturing artificial skin.

This removed the obstacles in the way of healing the patients.

The skin developed by Dr. Javed Ikram and his colleagues has been sent to the Drug Regulatory Authority of Pakistan (DRAP) for co-registration. It is hoped that it will yield positive results and that the problem of burnt patients will be solved soon.

Based on the agreement, the designated representative of the Pharmaceutical Association of Pakistan has approved that 20 pharmaceutical companies can manufacture this artificial skin.

In this regard, drugs prepared for treatment will be provided at cheap rates and can be exported if required.

Dr. Rauf Ahmed, who works in this department of Lahore Jinnah Hospital, which is reserved for burn patients, has also played a very important role in the preparation of the mentioned skin. Dr. Rauf Ahmed who is a Ph.D. in Microbiology told The Express Tribune about artificial skin that is made from the skin of the patient's body, which is not used during the operation, i.e. saved or used from animal skins. Goes, eg cow, buffalo, etc.

In the first stage, the upper layer of the skin is cleaned with chemical ingredients, which in medical terms is called "DE-EPIDERMALISATION". In the second stage, the part of the patient's body, which has been affected, is This is called "decellularization".

(DE-EPIDERMALISATION) is called. The patient has only one purpose to go through these two stages and that is to make his skin completely free of viruses so that the body's immune system can accept the new skin pieces.

In the third stage, the used skin is cleaned of charism. This multitude of tasks is finished by machines.

According to Dr. Rauf Ahmed, artificial skin can be preserved in a solid state for one year, while in cold storage it can be kept for six months. When it has to be used, it is diluted with different solutions.

Then, when it is placed on the affected area of ​​the patient's body, it becomes a part of the body. Then, over time, a natural membrane comes over it and thus it blends into the natural color of the skin. Is.

Dr. Rauf Ahmed said that the question may arise in people's minds how did the Pakistani scientist develop this artificial skin cheaper than the American scientists? Actually, it is just the difference in the chemical components and chemical compounds, The materials used to produce artificial skin are available here cheaply, so cheap skin production is possible.

Explaining the details about the skin, Dr. Rauf said that we can produce a small piece of skin in eight days, because our laboratory is small, so right now we can work on a small scale.

Like America and Europe, we do not have large, modern, and private laboratories, otherwise, we would have met the country's needs. Haseeb Khan, the representative of the Pakistan Pharmaceutical Association, said: "Now we have an agreement with Canada and Spain to buy artificial skin." Machinery to manufacture is desirable.

All the skins produced in our laboratory will be of international standards, whether it is eye tissue or kidney cells. It is difficult to say how long it will take to produce artificial skin on a large scale, but when it does, it will. The price will be very low.

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